Basis of selection of first and second line highly active antiretroviral therapy for hiv/aids on genetic barrier to resistance: A literature review

Abstract

The effectiveness of combination antiretroviral therapy (cART) continues to improve as treatment choices expand with the development of new antiretroviral agents and regimens. However, the successful long-term treatment of HIV/AIDS is under threat from the emergence of drug-resistant strains to multiple agents and entire drug classes.