Isatin-3-thiosemicarbazone as Chromogenic Sensor for the Selective Detection of Fluoride Anion

Abstract

In this study, we describe the anion recognition ability of isatin-3-thiosemicarbazone 2, which contains two different anion recognition units i.e. isatin NH and the thiourea moiety. Both have the ability to act as proton donors. Most importantly, a significant colour change of 2 was observed (from light yellow to reddish orange) in organic medium only after the addition of the F- A nion. No such colour change could be observed for any other anions including Cl-, Br-, I-, H2PO4-, NO2-, PF4-etc. The UV-Vis spectroscopic studies also indicate the potential of this compound for selective detection of fluoride anions. 1H-NMR titrations clearly indicate the formation of the 2.F- A nionic complex. The Density-functional theory (DFT) calculations are also performed to get further insights on the formation of 2.F-complex.Â