The Protective Role of Vitamin C against Formaldehyde inducedhepatotoxicity and nephrotoxicity in Male Rats

Abstract

Formaldehyde was administrated by gavage into male albino rats for 7 day as a single dose (1ml), and the histological changes in liver and kidney were investigated using paraffin method. This compound has caused hepatotoxicity which included degeneration of the hepatocytes, and appearing of inflammatory leucocytes. This compound has also caused nephrotoxicity which included high inflammation degree and degenerative effect on kidney tubule cells. When given to the formalin exposed rats, vitamin C caused recovery of the changes in the liver and kidney, i.e. it has been succeeded in playing a protective role against formalin hepatotoxicity and nephrotoxicity.