Immunolocalization of influenza a virus and markers of inflammation in the human Parkinson's disease brain

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Abstract

Although much is known regarding the molecular mechanisms leading to neuronal cell loss in Parkinson's disease (PD), the initiating event has not been identified. Prevailing theories including a chemical insult or infectious agent have been postulated as possible triggers, leading to neuroinflammation. We present immunohistochemical data indicating the presence of influenza A virus within the substantia nigra pars compacta (SNpc) from postmortem PD brain sections. Influenza A virus labeling was identified within neuromelanin granules as well as on tissue macrophages in the SNpc. Further supporting a role for neuroinflammation in PD was the identification of T-lymphocytes that colocalized with an antibody to caspase-cleaved Beclin-1 within the SNpc. The presence of influenza A virus together with macrophages and T-lymphocytes may contribute to the neuroinflammation associated with this disease. © 2011 Rohn, Catlin.

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Rohn, T. T., & Catlin, L. W. (2011). Immunolocalization of influenza a virus and markers of inflammation in the human Parkinson’s disease brain. PLoS ONE, 6(5). https://doi.org/10.1371/journal.pone.0020495

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