Magnesium: The Neglected Electrolyte? A Clinical Review

  • Sharma P
  • Chung C
  • Vizcaychipi M
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Magnesium, Mg2+, is the second most abundant\r<br />intracellular cation after potassium and the fourth most abundant in the body. It\r<br />was first isolated in 1808 by the English chemist, Sir Humphrey Davy. Magnesium\r<br />is essential to numerous biochemical reactions. It modulates key physiological\r<br />processes such as metabolic biochemistry, nucleic\r<br />acid synthesis, receptor-binding and ion flux. The western diet falls short of\r<br />the recommended daily allowance of 4.5 mg/Kg/day and important dietary sources\r<br />are seeds, grains, nuts and green vegetables. It is used as a therapeutic agent\r<br />in a broad range of pathologies: neurological,\r<br />cardiovascular, respiratory, gastrointestinal and obstetric.\r<br />The pharmacokinetics and pharmacodynamics of magnesium, as a drug, are not well\r<br />understood. Despite its fundamental importance to\r<br />human physiology, it remains an electrolyte that is not routinely measured as\r<br />part of the “urea & electrolytes” test and is the most overlooked electrolyte\r<br />deficiency in hospital inpatients. This review will summarise the importance of\r<br />magnesium homeostasis, its pharmacological effects and clinical applications.




Sharma, P., Chung, C., & Vizcaychipi, M. (2014). Magnesium: The Neglected Electrolyte? A Clinical Review. Pharmacology &amp; Pharmacy, 05(07), 762–772.

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