Clinical manifestations and survival of HIV/AIDS‐infected patients, southern region of Thailand

Abstract

Objective: The purpose of this study was to determine magnitude of clinical manifestations on survival of HIV/AIDS patients. Methods: The HIV/AIDS information system, a database containing demographic factors and clinical manifestations was used. A prospective, hospital-based cohort study was conducted in HIV/AIDS patients registered in both provincial and community hospitals from 14 provinces in southern region of Thailand, between January 1993 and April 2010. Totally, 52,459 of HIV/AIDS patients were routinely observed and followed up. One-fifth of the HIV/AIDS patients died (n=11,767, 22.43%) during the follow-up period. The outcome was timed from diagnosis of HIV/AIDS infection to death. Cox's proportional hazard model was used to analyze the magnitude of clinical manifestations on survival of HIV/AIDS patients. Results: A statistically significant corresponding risk of clinical manifestation on death was found. HIV/AIDS patients who had clinical manifestations including: invasive cervical cancer (HR=0.14, 95% CI: 0.44 to 0.43), herpes simplex (0.81, 0.66 to 0.98), histoplasmosis (0.67, 0.46 to 0.97), Mycobacterium other species (0.78, 0.64 to 0.97) were more likely to have a longer life. However, patients expressed clinical manifestations including; candidiasis (1.45, 1.34 to 1.56), cryptococcosis (1.77, 1.64 to 1.91), cytomegalovirus retinitis (1.58, 1.26 to 1.98), HIV encephalopathy (2.17, 1.92 to 2.47), Mycobacterium avium complex (1.76, 1.32 to 2.33) Mycobacterium tuberculosis (1.25, 1.21 to 1.30), pneumonia recurrent (1.78, 1.61 to 1.96), Pneumocystis carinii (1.71, 1.63 to 1.78), salmonella septicemia (1.85, 1.43 to 2.39) toxoplasmosis (1.47, 1.30 to 1.66) and wasting syndrome (2.13, 2.04 to 2.21) were more likely to die faster. Conclusion: In conclusion, HIV/AIDS patients expressed clinical manifestations which were a risk of death must be monitored closely and intensively care to extend their life and increase their quality of life.