The accurate assessment of body fluid volume is important in many clinical situations, especially in the determination of "dry weight" in a dialysis setting. Currently, no clinically applicable diagnostic system exists to determine the mechanical properties that accurately characterize peripheral edema in an objective and quantitative manner. We have developed a method for quantifying the impact of compression on the electrical properties of tissue by measuring stress-induced changes in bioimpedance (BIS). Using this method, we simultaneously measured the impedance and mechanical response of a tissue mimicking material (tofu) under both quasi-static and dynamic loading conditions. Our results demonstrate a temporal quantification of viscoelastic properties using a viscoelastic phantom tissue model.
Koziol, L., Pitre, J. J., Bull, J. L., Dodde, R. E., Kruger, G., Vollmer, A., & Weitzel, W. F. (2014). The feasibility of using compression bioimpedance measurements to quantify peripheral edema. Journal of Electrical Bioimpedance, 5(1), 99–109. https://doi.org/10.5617/jeb.929