Alkynylation-Desilylation-Alkynylation-Cycloisomerization (ADAC) Three-Component Synthesis of 2,2′-Biindolyls – Concise Synthesis of Tjipanazole I

Abstract

A sequentially Pd/Cu-catalyzed alkynylation-desilylation-alkynylation-cycloisomerization (ADAC) process in the sense of a consecutive three-component reaction using TIPS-butadiyne as a four carbon building block gives a rapid and efficient access to 2,2′-biindolyls in a one-pot fashion. This facile entry to unsymmetrically substituted title compounds has been employed in a concise two-step synthesis of the alga alkaloid tjipanazole I.