Abstract
Lipophilic cationic technetium-99m-complexes are widely used for myocardial perfusion imaging (MPI). However, inherent uncertainties in the supply chain of molybdenum-99, the parent isotope required for manufacturing 99Mo/99mTc generators, intensifies the need for discovery of novel MPI agents incorporating alternative radionuclides. Recently, germanium/gallium (Ge/Ga) generators capable of producing high quality 68Ga, an isotope with excellent emission characteristics for clinical PET imaging, have emerged. Herein, we report a novel 68Ga-complex identified through mechanism-based cell screening that holds promise as a generator-produced radiopharmaceutical for PET MPI. Copyright:
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CITATION STYLE
Sharma, V., Sivapackiam, J., Harpstrite, S. E., Prior, J. L., Gu, H., Rath, N. P., & Piwnica-Worms, D. (2014). A Generator-produced gallium-68 radiopharmaceutical for PET imaging of myocardial perfusion. PLoS ONE, 9(10). https://doi.org/10.1371/journal.pone.0109361
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