Acquired inhibitors to multiple coagulation factors (V, IX, and XII) identified in a unique patient with hepatocellular carcinoma

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Abstract

An acquired formation of inhibitors to coagulation factors is a rare type of coagulopathy. The development of inhibitors for multiple coagulation factors has never been reported. A 75-year-old Japanese female underwent interventional therapy for hepatocellular carcinoma. Five days after the last intervention, her prothrom-bin time decreased to 10%, and her activated partial thromboplastin time (APTT) lengthened to 265.1 sec. The activities for coagulation factors showed significantly reduced activities (<10%) of factors V, IX, and XII. A cross-mixing test demonstrated an inhibitor pattern, and inhibitory antibodies against factors V, IX, and XII were detected. We discuss our patient’s etiology and pathogenesis.

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Imataki, O., Arai, T., & Uemura, M. (2017). Acquired inhibitors to multiple coagulation factors (V, IX, and XII) identified in a unique patient with hepatocellular carcinoma. Internal Medicine, 56(10), 1203–1206. https://doi.org/10.2169/internalmedicine.56.7845

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