Safety and Tolerability of a Rapidly Escalating Dose-Loading Regimen for Risperidone

Abstract

Reports an error in the original article by D. Feifel et al (Journal of Clinical Psychiatry, 2000[Dec], Vol 61[12], 909-911). The article did not explicitly mention the specific methodology used in collecting the safety and tolerability data. The authors requested that this article be retracted from the scientific literature. (The following abstract of this article originally appeared in record [rid]2001-14316-002[/rid].) Investigated the safety and tolerability of a rapid oral-loading regimen for risperidone developed to achieve therapeutic doses of this antipsychotic within 24 hrs. Rapid-loaded risperidone was initiated with 1 mg. Subsequent doses were increased by 1 mg every 6-8 hrs up to 3 mg. Of a sample of 11 consecutive inpatients admitted to an acute psychiatric facility who were treated with this protocol, 7 tolerated the most rapid titration, achieving a standing dose of 3 mg b.i.d. in 16 hrs. Three required a slightly slower titration and achieved this target dose in 24 hrs. One patient could not tolerate the 3-mg dose but tolerated a standing regimen of 2 mg t.i.d. No patient experienced serious extrapyramidal side effects, sedation, or any other adverse event during the rapid titration, and in no case did risperidone have to be discontinued. (PsycINFO Database Record (c) 2013 APA, all rights reserved)