Irisin impact as a medication that ameliorate and hinder the development of insulin resistance associated disorders without regular exercise (experimental study)

Abstract

Slothful life style and lack of regular physical activity are the main causes of obesity, obesity-induced metabolic disorders. The aims of this study were to consolidation the harmony of serum Irisin with rats' fat development. Thinking over the innovation, can Irisin be therapeutic for metabolic disorders without regular exercise. This prospective experimental study was included 120 Western rats. The study had undergo two lines first was the correction of inducible obesity & diabetes; second was the prevention of mentioned inducible conditions, both lines was done by subjecting the rats to subcutaneous injection of prepared Irisin solution (100 ng/ml). Inducible obese type 2 diabetic (T2DM) rats had significantly higher serum Irisin, insulin level & fasting glucose (S.F.G.) in comparison with inducible obese rats & normal weight rats. Obese rats that were injected with 100 ng/ml of recombinant Irisin had highly significant lower weight mean and S.F.G. than obese rats control. Established diabetic rats with Irisin injection was significantly corrected, with their weight , serum glucose , and insulin after 26 days of irisin treatment. Findings showed that Irisin may act as reformation effect on new onset type 2 diabetics' rats; as well as it may have intensive defiance against fatness .