Preparation and Characterization of IPN Microspheres for Controlled Delivery of Naproxen

Abstract

Interpenetrating network (IPN) microspheres of sodium alginate (NaAlg) and poly (vinyl alcohol) (PVA) were prepared and crosslinked with glutaraldehyde (GA) by using the water in oil (W/O) emulsification method to deliver naproxen sodium (NS). NS was successfully encapsulated into IPN microspheres in different ratios of NaAlg and PVA (w/w), drug loading percentage (w/w) and crosslinking time. Crosslink density of the matrices was affected by the time of crosslinker. The prepared microspheres were characterized by Fourier transform infrared spectroscopy (FTIR). Pictures of selected microspheres were determined using optic microscope. Results confirmed the dispersion of NS in the microspheres. Release of NS from the microspheres was investigated in pH 1.2, 6.8 and 7.4 media for two hours respectively. The highest NS release was obtained as 92% (w/w) by using UV spectroscopy. Equilibrium swelling was performed in pH 7.4 buffer solution at 37℃.