Surveillance of Rotavirus Diarrhea in Hasan Sadikin Hospital Bandung

Abstract

The diarrhea morbidity in Indonesia has increased, however, all the reports had not been done carefully, so that accurate surveillance are essential for improving quality of morbidity data. To determine the prevalence and clinical manifestations of rotavirus diarrhea and to characterize the circulating rotavirus strains, children below 5 years old who were admitted to Hasan Sadikin Hospital, Bandung because of diarrhea, from January 2006 through March 2007 were enrolled in a surveillance study and had stool specimens tested for the presence of rotavirus using enzyme immunoassay (EIA). The strains of rotavirus were determined using reverse transcriptase-polymerase chain reaction (RT-PCR). Rotavirus were detected in 47.8% analyzed samples (87/184), G and P-genotype of rotavirus were G[1] (37.5%) and P[6] (53.5%). Most subjects were males (56%), 6-11 months of age (35%). Most common clinical manifestations besides diarrhea were dehydration (72.7%) and vomiting (50%). Subjects with positive rotavirus more common had dehydration (72% vs 28%) and vomiting (61% vs 39%). In conclusion, vomiting and dehydration are the prominent clinical manifestations of diarrhea with positive rotavirus infection. G1 and P6 are the most common genotype of rotavirus. [MKB. 2010;42(4):155-60].