Efficient synthesis of functionalized α-aryl α-aminoesters via reaction of polyfunctional diarylzincs with a glycine cation equivalent

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Abstract

Functionalized diarylzine reagents, easily available from the corresponding aryl halides by a halogen-lithium exchange followed by transmetalation with ZnCl2 react with a glycine cation equivalent to afford substituted α-aryl α-amino esters in good yields.

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Lamaty, F., Lazaro, R., & Martinez, J. (1997). Efficient synthesis of functionalized α-aryl α-aminoesters via reaction of polyfunctional diarylzincs with a glycine cation equivalent. Tetrahedron Letters, 38(19), 3385–3386. https://doi.org/10.1016/S0040-4039(97)00625-4

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