Immunomodulatory effect of Tinospora cordifolia and Centella asiatica and its modulation on cyclophosphamide challenge

Abstract

See, stats, and : https : / / www . researchgate . net / publication / 230792903 Immunomodulatory cordifolia modulation . . . Article DOI : 10 . 3742 / OPEM . 2008 . 8 . 4 . 380 CITATIONS 4 READS 76 3 , including : Nasir King 59 SEE All - text , letting . Available : Nasir Retrieved : 06 SUMMARY Ethanolic extracts of T . cordifolia and C . asiatica were evaluated for immunostimulatory effect in mice against sheep RBCs as antigen by three models viz . delayed type hypersensitivity reaction , percent change in neutrophil count and haemagglutination titre . Immunostimulatory effect in the presence of immunosuppressant agent , cyclophosphamide (100 mg / kg , i . p .) was also investigated . T . cordifolia and C . asiatica significantly (p < 0 . 001 , p < 0 . 05 respectively) enhanced foot pad thickness when measured after 24 hours of sheep RBC antigen challenge . Both the plant materials increased foot pad thickness even after being subjected to immunosuppressant exposure . T . cordifolia revealed enhanced neutrophil counts , while C . asiatica had no significant effect on neutrophil counts . T . cordifolia exhibited significantly (P < 0 . 01) elevated neutrophil levels even in the presence of cyclophosphamide administration . Both the plants exhibited humoral antibody response , as haemagglutination titre values were significantly high as compared to control . T . cordifolia and C . asiatica could combat immunosuppressant effect of cyclophosphamide (P < 0 . 01) . This suggests that T . cordifolia and C . asiatica can be regarded as biological response modifiers and can be utilized for the development of immunostimulating agent among plant sources .