Successful antiviral treatment after 6 years of chronic progressive neurological disease attributed to VZV brain infection

Abstract

We describe an extraordinary case of an immunocompetent patient who developed sacral-distribution zoster, followed 3 months later by neurological disease that progressed for 6 years and was attributed to varicella zoster virus (VZV) infection of the brain. Despite the prolonged infection, neurologic symptoms and signs resolved rapidly and completely after treatment with intravenous acyclovir.