Presence of Viral DNA in Whole-Genome Sequencing of Brain Tumor Tissues from The Cancer Genome Atlas

Abstract

Determining the potential role of viruses in brain tumorigenesis has proven to be extremely elusive. Even with the development of newer technologies, establishing the presence of the virus, the temporality of the infection, and the influence of viral factors in carcinogenesis remains challenging. A few recent studies have contributed to the controversy surrounding the question of whether viral factors could explain a proportion of glioma risk (1–3).