Schiff base, 6-amino-2-[(4-(dimethylamino) benzylidene)amino]hexanoic acid and its lanthanide (III) complexes have antioxidant and antimicrobial activities

Abstract

The titled Schiff base, 6-amino-2-[(4-(dimethylamino)benzylidene)amino]hexanoic acid was synthesized by condensing N,N-dimethyl aminobenzaldehyde and Lysine together using ethanol as a solvent. The Schiff base was isolated and further reacted with Ce(NO 3 ) 3 .6H 2 O and La(NO 3 ) 3 .6H 2 O, to afford their respective complexes. FTIR, 1 H NMR, UV-Vis and ICP techniques were used the characterization and structure elucidation of the prepared Schiff base and its La (III) and Ce (III) complexes. The proposed geometries of the complexes were established on the basis of metal ligand ratio through ICP. Schiff base showed antioxidant activity against diphenylpicrylhydrazyl (DPPH). The results showed that metal complexes are good antioxidant agents as compared to Trolox (standard) and ligand was less active as compared to Trolox. The Schiff base ligand and its metal (III) complexes showed antibacterial activity against E. coli, S. aureus by disc diffusion method and antifungal activity against Macrophomina phaseolina, Fusarium oxysporum. The metal (III) complexes are highly active under permissible limits.