The Research Progress in Transforming Growth Factor-β2

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Abstract

Transforming growth factor-beta 2 (TGF-β2), an important member of the TGF-β family, is a secreted protein that is involved in many biological processes, such as cell growth, proliferation, migration, and differentiation. TGF-β2 had been thought to be functionally identical to TGF-β1; however, an increasing number of recent studies uncovered the distinctive features of TGF-β2 in terms of its expression, activation, and biological functions. Mice deficient in TGF-β2 showed remarkable developmental abnormalities in multiple organs, especially the cardiovascular system. Dysregulation of TGF-β2 signalling was associated with tumorigenesis, eye diseases, cardiovascular diseases, immune disorders, as well as motor system diseases. Here, we provide a comprehensive review of the research progress in TGF-β2 to support further research on TGF-β2.

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Wang, M. Y., Liu, W. J., Wu, L. Y., Wang, G., Zhang, C. L., & Liu, J. (2023, December 1). The Research Progress in Transforming Growth Factor-β2. Cells. Multidisciplinary Digital Publishing Institute (MDPI). https://doi.org/10.3390/cells12232739

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