Chitosan patch scaffold for repair of chronic safe tympanic membrane perforation

Abstract

Abstract Objective: This study was designed to evaluate the performances of chitosan patch myringoplasty in patients with small and medium sized chronic safe tympanic membrane (T.M) perforations. Patients and methods: After preparation of the chitosan patch scaffold (CPS), 60 consecutive dry small and medium sized(from <3 mm up to 5 mm) central tympanic membrane perforations were included in this study. Results: Healing of T.M perforations was achieved in 14 out of 19 in small perforations (73.68%) and 25 out of 41 in medium sized perforations (60.97%) also significant improvement of hearing and tinnitus were achieved post-operatively. Conclusion: Myringoplasty by water insoluble chitosan patch scaffold with 3% chitosan and 3% glycerol is easy, safe and quick method. It can be done in outpatient clinic without risk of general anesthesia and with noticeable reduction in the time of operation.