Nickel and Palladium Complex Catalyzed Cross-Coupling Reactions of Organometallic Reagents with Organic Halides

Abstract

The discovery in 1972 by two research groups that dihalodi- phosphinenickel(II) complexes exhibit extremely high catalytic activity for selective cross-coupling of Grignard reagents with sp2-carbon halides has aroused wide-spread interest in application in organic synthesis of this type and related reactions involving other organometallics than Grignard reagents and not only nickel but also palladium complexes as catalysts. In this lecture several aspects of the title subject will be described centering argument on the Grignard coupling using a variety of phosphine-nickel and -palladium complexes of the formula MCl2L2(M = Ni or Pd; L2 = diphosphine) as catalyst precursors. © IUPAC