Synthetic strategies for radioligands for in vivo imaging of brain cannabinoid type-1 receptors

Abstract

Despite its abundant expression in the brain, the cannabinoid type-1 (CB1) receptor was discovered only in 1988. During the last decade, efforts from several research groups have made it possible to visualize the CB1 receptor in vivo to unravel its role in the brain physiology and pathology. This review discusses strategies for (radio)synthesis of radioligands for in vivo imaging of CB1 receptors. Copyright © 2013 John Wiley & Sons, Ltd.