Synthesis and preliminary cytotoxic and antifungal evaluation of some 6-N,N-dialkyl 2-aryl-4(3H)-quinazolinone derivatives

Abstract

Some new 2-aryl-4-quinazolinone derivatives bearing a cyclic amino group at position 6 were prepared and their preliminary cytotoxic and antifungal evaluation is reported. They all showed a moderate cytotoxicity suggesting that not only the oxidation state of the N1-C2 bond is a crucial factor for this kind of biological activity. These quinazolinones were tested against several yeast, filamentous and dermatophyte fungi showing all to be inactive.