Conjugate additions to α,β-unsaturated carbonyl compounds in aqueous media

Abstract

Alkyl halides in the presence of zinc copper couple add smoothly to α-enones and α-enals in aqueous solvents. Sonication enhances the efficiency of the process, which leads to the conjugate adducts in high yields. The reaction follows most probably a radical pathway, and can be used for the addition of functionalized groups. © 1986.