Pyrrolidines and Piperidines by Ligand‐Enabled Aza‐Heck Cyclizations and Cascades of N ‐(Pentafluorobenzoyloxy)carbamates

  • Hazelden I
  • Carmona R
  • Langer T
  • et al.
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Abstract

Ligand‐enabled aza‐Heck cyclizations and cascades of N ‐(pentafluorobenzoyloxy)carbamates are described. These studies encompass the first examples of efficient non‐biased 6‐ exo aza‐Heck cyclizations. The methodology provides direct and flexible access to carbamate protected pyrrolidines and piperidines.

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Hazelden, I. R., Carmona, R. C., Langer, T., Pringle, P. G., & Bower, J. F. (2018). Pyrrolidines and Piperidines by Ligand‐Enabled Aza‐Heck Cyclizations and Cascades of N ‐(Pentafluorobenzoyloxy)carbamates. Angewandte Chemie, 130(18), 5218–5222. https://doi.org/10.1002/ange.201801109

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