Synthesis of 3,4-dihydro-2H-1,3,5-thiadiazines

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Abstract

3,4-Dihydro-2H-1,3,5-thiadiazines substituted at the 3 and 6 positions were synthesized by treatment of N-substituted N,N-bis(1H-1,2,3-benzotriazol-1-ylmethyl)-amines with thioamides and zinc bromide in dry CH2Cl2 at room temperature for 48-60 h in 48-80% yields.

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Katritzky, A. R., Vakulenko, A. V., Xu, Y. J., & Steel, P. J. (2002). Synthesis of 3,4-dihydro-2H-1,3,5-thiadiazines. Journal of Organic Chemistry, 67(14), 4960–4962. https://doi.org/10.1021/jo020033s

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