Regulation of phospholipid synthesis in yeast

Abstract

Phospholipid synthesis in the yeast Saccharomyces cerevisiae is a complex process that involves regulation by both genetic and biochemical mechanisms. The activity levels of phospholipid synthesis enzymes are controlled by gene expression (e.g., transcription) and by factors (lipids, water-soluble phospholipid precursors and products, and covalent modification of phosphorylation) that modulate catalysis. Phosphatidic acid, whose levels are controlled by the biochemical regulation of key phospholipid synthesis enzymes, plays a central role in the regulation of phospholipid synthesis gene expression.-Carman, G. M., and G-S. Han. Regulation of phospholipid synthesis in yeast. Copyright © 2009 by the American Society for Biochemistry and Molecular Biology, Inc.