Highly modular construction of differently substituted dihydrodibenzo[a,c] cycloheptenes: Fast and efficient access to derivatives of 2,2′-cyclo-7, 8′-neolignans

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Abstract

Tying the knot: Two aryl units are linked in a one-pot reaction. In a subsequent MoCl5-mediated oxidative cyclization dihydrodibenzo[a,c] cycloheptenes are provided in excellent yields and an unusually broad range of functional groups are tolerated (see scheme).

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Kramer, B., & Waldvogel, S. R. (2004). Highly modular construction of differently substituted dihydrodibenzo[a,c] cycloheptenes: Fast and efficient access to derivatives of 2,2′-cyclo-7, 8′-neolignans. Angewandte Chemie - International Edition, 43(18), 2446–2449. https://doi.org/10.1002/anie.200353597

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