Non-metastatic basaloid squamous cell carcinoma of the uterine cervix in a woman with history of subtotal hysterectomy

Abstract

Introduction: Basaloidsquamouscell carcinoma (BSCC) of the cervix isanuncommontumorin female genital tract. The aggressive clinical behavior makes this entity distinguished from other SCC subtypes. Case Presentation:We described a case of basaloid squamous cell carcinoma in uterine cervix in a 62-year oldwomanwith previous subtotal hysterectomy. Clinical and radiologic examination suggested a 3 cm mass in cervical stump involving left parametrium. She underwent trachelectomy and lymph node dissection followed by adjuvant radiochemotherapy. The light microscopy and immunohistochemistry warranted the basaloid SCC diagnosis that was suspected in pre-operational biopsy. The small, round to ovalshaped cells with scant cytoplasm and hyperchromatic nuclei were positive for cytokeratin AE1/AE3 (CK AE1/AE3) and negative for p63, C-KIT, chromogranin and synaptophysin. Conclusions: Although this tumor has an aggressive behavior, this is not enough to substantiate that BSCC has a poorer medical outcome as compared to conventional SCC of the cervix.