Effect of CD3/CD28 Bead-Activated and Expanded T Cells on Leukemic B Cells in Chronic Lymphocytic Leukemia

Abstract

We read with interest the paper by Bonyhadi et al. ([1][1]) published February 15, 2005. We have, however, two concerns. CD3/CD28 stimulation resulted in successful expansion of T cells from B-CLL PBMC samples. The authors state that this was associated with a rapid decrease in numbers of leukemic