Type i phosphotidylinosotol 4-phosphate 5-kinase regulates osteoclasts in a bifunctional manner

Abstract

Background: PI(4,5)P2, mainly synthesized by PIP5KI, is essential for normal cell function. Results: Deficiency or overexpression of PIP5KI, which results in decrease or increase of PI(4,5)P2, respectively, impairs osteoclast differentiation and function. Conclusion: Optimal PIP5KI and PI(4,5)P2 expression are important for osteoclast function. Significance: This is the first demonstration that PIP5KI regulates cells in a bifunctional manner. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.