Encapsulation of three different crude extracts rich in triterpenes in a biocompatible polymer and their evaluation in vitro for further applications as anti-inflammatory and/or anti-tumour alternative therapeutic agents

Abstract

Medicinal plants continue to be of real interest to researchers in interdisciplinary fields such as chemistry, pharmacy, medicine. Due to the metabolites in which it abounds, the plant material can successfully represent both a prophylactic and curative treatment. At present, countless studies, both in vitro and in vivo, are conducted to elucidate the pharmacological effects and establish the mechanisms involved. The actual experiment was purposed to evaluate the activity of raw birch bark, apple pomace and olive leaves extracts rich in triterpenes, formulated as PLGA nanoparticles, on normal/healthy different cell lines immortalized and of primary origin, such as keratinocytes, dermal fibroblasts, and gingival fibroblasts.