The Effect of Jujube Leaf Extract in Preventing Memory Scores Deficit in White Wistar Rat Hypertension Model

Abstract

Memory impairment is one of the effects caused by hypertension. Jujube leaves (Ziziphus mauritiana Lam) have active ingredients which are believed to control hypertension and, therefore, prevent memory deficit, especially spatial memory in white rats. The aim of the study was to determine the effect of jujube leaves extract (Ziziphus mauritiana Lam) on the memory score of white rats with hypertension induced by NaCl and Prednisone. The study was a true experimental with a post-test-only control group design. Rats were divided into five groups consisting of two control groups and three groups with jujube leaves extract: 200mg/KgBW/day, 400mg/KgBW/Day, and 800mg/KgBW/Day. Memory functions were measured by Radial Arm Maze to measure spatial memory function. Data were analyzed with One-Way ANOVA and then Post-hoc Bonferroni. All groups were found to be significant (p = 0.00) in One-Way ANOVA test. In a Post hoc test, only group 3 with a dose of 800mg/KgBW/day was found to be significant (p = 0.00) to prevent memory score deficit in white hypertensive Wistar rats induced by NaCl and Prednisone. Jujube leaves extract (Ziziphus mauritiana Lam) can prevent memory score deficit in white Wistar rats with hypertension. Keywords: hypertension, memory function, jujube leaves