Oncolytic virotherapy for ovarian cancer

Abstract

See, stats, and : https : / / www . researchgate . net / publication / 256498873 Oncolytic . Article READS 26 All - text , letting . Available : Masmudur Retrieved : 28 Abstract : In the past two decades , more than 20 viruses with selective tropism for tumor cells have been developed as oncolytic viruses (OVs) for treatments of a variety of malignancies . Of these viruses , eleven have been tested in human ovarian cancer models in preclinical studies . So far , nine phase I or II clinical trials have been conducted or initiated using four different types of OVs in patients with recurrent ovarian cancers . In this article , we summarize the different OVs that are being assessed as therapeutics for ovarian cancer . We also present an overview of recent advances in identification of key genetic or immune - response pathways involved in tumorigenesis of ovarian cancer , which provides a better understanding of the tumor specifici - ties and oncolytic properties of OVs . In addition , we discuss how next - generation OVs could be genetically modified or integrated into multimodality regimens to improve clinical outcomes based on recent advances in ovarian cancer biology .