Rh(III)-TsDPEN, an immobilized analog of the well-known [Cp*Rh(bpy)(H2O)] 2+ was evaluated as a heterogeneous, recyclable regeneration catalyst for reduced oxidoreductase cofactors [NAD(P)H]. Repeated use of this catalyst was established and the catalytic properties were initially investigated. Apparently, Rh(III)-TsDPEN is prone to severe diffusion limitations, necessitating further developments. Overall, a promising concept for chemoenzymatic redox catalysis is proposed, which may overcome some of the current limitations such as catalyst cost and incompatibility of Rh with some biocatalysts.
De Torres, M., Dimroth, J., Arends, I. W. C. E., Keilitz, J., & Hollmann, F. (2012). Towards recyclable NAD(P)H regeneration catalysts. Molecules, 17(8), 9835–9841. https://doi.org/10.3390/molecules17089835