Inhibition of Adenosine 3',5'-Cyclic Monophosphate Phosphodiesterase by Flavonoids From Licorice Roots and 4-Arylcoumarins

Abstract

Isoliquiritigenin, glabridin, licoarylcoumarin and licoricidin were identified as strong inhibitors of adenosine 3 ',5'-cyclic monophosphate (cAMP) phosphodiesterase in waste materials which were obtained during the industrial extraction of glycyrrhizin from licorice roots. The structure-activity relationships of 12 flavonoids from licorice roots and 34 4-arylcoumarins were studied. In 4-arylcoumarins, 5,7-dihydroxy derivatives were generally highly inhibitory towards cAMP phosphodiesterase. © 1991, The Pharmaceutical Society of Japan. All rights reserved.