Abstract
Incubation of cell cultures of fibroblasts from mice areolar tissue (L-929) or epithelial cells from human larynx carcinoma (HEp-2) with any of 10 sesquiterpenic lactones (0.1-100 μg/mL) resulted in cytotoxicity as evidenced by inhibition of cell growth. The ED50s for viguiestenin (I) [54153-71-8], zexbrevin A [28644-87-3], zexbrevin B [34302-19-7], budlein A [59481-48-0], calaxin [30412-86-3], and orizabin [34367-14-1] were 5.5, 1, 1, 1, 1, and 4.2 μg/mL, resp. These compds. have potential as anticancer agents. The ED50s of the other 4 lactones tested were 15-66 μg/mL. The mol. structure-activity relationships for each of the lactones are discussed. [on SciFinder(R)]
Author supplied keywords
- Animal cell (HEp-2, sesquiterpenoidal lactone toxi
- Fibroblast (sesquiterpenoidal lactone toxicity to
- Lactones Role: PRP (Properties) (sesquiterpenoidal
- Molecular structure-biological activity relationsh
- Sesquiterpenes and Sesquiterpenoids Role: PRP (Pro
- Toxicity (of sesquiterpenoidal lactones, to cell c
- cytotoxicity
- lactone
- sesquiterpene
- structure
Cite
CITATION STYLE
Tellez-Martinez, J., Taboada, J., & Gonzalez-Diddi, M. (1980). Cytotoxicity of some sesquiterpene lactones in vitro. Section Title: Pharmacodynamics, 11(4), 435–443.
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