Recently, Schulz and colleagues have contributed to the ongoing controversy on the unproven role of oxidative stress in the aging process in their well-performed study 'Glucose restriction extends Caenorhabditis elegans life span by inducing mitochondrial respiration and increasing oxidative stress' (Cell Metab 2007, 6: 280-293). Here, we suggest an alternative hypothesis that reductive stress can prevent calorie-restriction induced life span extension. We draw attention to this condition as an explanation for some contradictory observations including the deleterious effects from antioxidants. © 2008 Ralser and Benjamin; licensee BioMed Central Ltd.
CITATION STYLE
Ralser, M., & Benjamin, I. J. (2008). Reductive stress on life span extension in C. elegans. BMC Research Notes, 1. https://doi.org/10.1186/1756-0500-1-19
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