Highlights on Evidence-Based Treatment Strategies for COVID-19: a Review

Abstract

21st century is considered a well-modernized era, but recently a new public health emergency triggered by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) with the emergence of treatment therapy globally. WHO named it Covid-19 on February 11, 2020, and announced this rapidly spreading corona outbreak a pandemic on March 11, 2020. Currently, there is no known specific vaccine or drug to treat COVID-19. The Coronavirus was first noticed in Wuhan Hubei city of China, in December 2019. COVID-19 originated from an animal source, thus named SARS-CoV-2 that causes mild to severe illness from the common cold to diseased conditions such as Severe Acute Respiratory Syndrome (SARS) & the Middle East Respiratory Syndrome (MERS). Various key proteins as targets have been identified, which are responsible for its virulence and cause infections in humans. Since it has been started, much research has been conducted and still going on to develop a suitable candidate to inhibit its virulence targeting its key protein targets with in-silico docking studies. This review highlights the viral introduction, its genome, spike protein interaction WHO guidelines and current treatment or drugs, and in-silico docking studies related to SARS-CoV-2.