Abstract
Agonistic and antagonistic properties of novel tetracyclic benzomorphans (1-4) were evaluated in vivo and in vitro opioid receptor interaction tests. Seven-membered derivatives (1,3) showed synergism with morphine analgesia. Six-membered derivatives (2,4) demonstrated antagonist opioid characters. © 1983, The Pharmaceutical Society of Japan. All rights reserved.
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Hori, M., Kataoka, T., Shimizu, H., Imai, E., Suzuki, Y., Kawamura, N., … Niwa, M. (1983). Agonist-antagonist properties of 5,7-ethano-4,5,5a,6,7,11b-hexahydro-2,6, 7-trimethyl-1h-benzo[g]homoquinolin-9-ol and 4,6-ethano-3,4,4a,5,6,10b-hexahydro-2,5,6-trimethylbenzo[f]quinolin-8-ol. Chemical and Pharmaceutical Bulletin, 31(7), 2520–2522. https://doi.org/10.1248/cpb.31.2520
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