Ent-kaurane diterpenoids and other constituents from the stem of xylopia laevigata (Annonaceae)

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Abstract

Phytochemical investigation of the hexane extract from the stem of Xylopia laevigata led to the isolation of the ent-kaurane diterpenoids, ent-kaur-16-en-19-oic acid, 4-epi-kaurenic acid, ent-16b-hydroxy-17-acetoxy- kauran-19-al, ent-3b-hydroxy-kaur-16- en-19-oic acid, and ent-16b,17-dihydroxy- kauran-19-oic acid, as well as spathulenol and a mixture of b-sitosterol, stigmasterol and campesterol. The identification of the compounds was performed on the basis of spectrometric methods including GC-MS, IR, and 1D and 2D NMR. Potent larvicidal activity against Aedes aegypti larvae with LC50 of 62.7 mg mL-1 was found for ent-3b-hydroxykaur- 16-en-19-oic acid. This compound also showed significant antifungal activity against Candida glabrata and Candida dubliniensis with MIC values of 62.5 mg mL-1.

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Silva, D. M., Costa, E. V., De Lima Nogueira, P. C., De Souza Moraes, V. R., De Holanda Cavalcanti, S. C., Salvador, M. J., … Ferreira, A. G. (2012). Ent-kaurane diterpenoids and other constituents from the stem of xylopia laevigata (Annonaceae). Quimica Nova, 35(8), 1570–1576. https://doi.org/10.1590/S0100-40422012000800015

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