Microwave-assisted Passerini reactions under solvent-free conditions

Abstract

Various α-acyloxy carboxyamides were easily obtained combining three building blocks in one step: a carboxylic acid, an aldehyde and an isonitrile (Passerini reaction), using microwave irradiation under solvent-free conditions. The products were obtained in good yields (61-90%) and in short reaction times (≤ 5 min), using two different temperatures (60 and 120 °C). At 120 °C, the yields were higher and the reactions faster (≤ 1 min). Most of the obtained products are multifunctional allowing their application in consecutive Passerini reactions. © 2011.