Salts of therapeutic agents: Chemical, physicochemical, and biological considerations

14Citations
Citations of this article
88Readers
Mendeley users who have this article in their library.

Abstract

The physicochemical and biological properties of active pharmaceutical ingredients (APIs) are greatly affected by their salt forms. The choice of a particular salt formulation is based on numerous factors such as API chemistry, intended dosage form, pharmacokinetics, and pharmacodynamics. The appropriate salt can improve the overall therapeutic and pharmaceutical effects of an API. However, the incorrect salt form can have the opposite effect, and can be quite detrimental for overall drug development. This review summarizes several criteria for choosing the appropriate salt forms, along with the effects of salt forms on the pharmaceutical properties of APIs. In addition to a comprehensive review of the selection criteria, this review also gives a brief historic perspective of the salt selection processes.

Cite

CITATION STYLE

APA

Gupta, D., Bhatia, D., Dave, V., Sutariya, V., & Gupta, S. V. (2018). Salts of therapeutic agents: Chemical, physicochemical, and biological considerations. Molecules. MDPI AG. https://doi.org/10.3390/molecules23071719

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free