Comparison of CA 125, CA 72-4, risk of malignancy index and depriest scoring system in the differentiation between benign and malignant adnexal masses

Abstract

Objective: The aim of this study is to compare prospectively CA 125, CA72-4, risk of malignancy index (RMI) and DePriest morphological scoring system in differentiation between benign and malignant adnexal masses. Method: Data of 116 cases operated due to adnexal mass were analyzed. Blood samples were taken from the patients for CA 125 and CA 72-4 before the operation. In ultrasonographic examination, risk of malignancy index (RMI) and DePriest morphological scoring system were used. SPSS 22.0 (Statistical Package for Social Sciences) for Windows program was used for analyses. Results: The mean age was 53.8±5.4 years in malignant group which was significantly higher than the mean age of benign group (43.3±5.5 years). However, the weight, body mass index (BMI), gravidity and parity rates were similar and not statistically significant. CA 125, CA 72-4, RMI and DePriest morphological scoring system were significantly higher in malignant group than benign group (p<0,05). Pelvic pain was the most common admission complaint (56%: n=65) followed by referral from another hospital (32.7%: n=38). Benign masses were reported in 88 (75,9%), and malignant masses in 28 (24,1%) of 116 patients. Endometrioma (n=19, 16,3%) and serous cystadenoma (n=19, 16,3%) were the most common pathological entities in the benign group, while serous cystadenocarcinoma (n=13 11,2%) was the most common pathological entity in the malignant group. Conclusion: CA72-4 did not have enough effectivity to predict the results of pathology in adnexal masses because of its low sensitivity. Significant efficiency of RMI and CA 125 were monitored. DePriest morphological scoring system was found to be more effective than CA 125, CA 72-4 and RMI in differentiation between benign, and malignanat adnexal masses.