Blood flow during cardiopulmonary resuscitation with simultaneous compression and ventilation in infant pigs

Abstract

We determined whether the simultaneous chest compression and ventilation (SCV) technique of car-diopulmonary resuscitation (CPR) enhances cerebral (CBF) and myocardial (MBF) blood flows and cerebral O3 uptake in an infant swine model of CPR as it does in most adult animal CPR models. We also tested whether SCV-CPR sustains CBF and MBF for prolonged periods of CPR when these flows ordinarily deteriorate. CPR was performed in two groups (n = 8) of pentobarbital anesthetized piglets (3.5-5.5 kg) with continuous epinephrine infusion (10 μg/kg/min). Conventional CPR was performed at 100 compressions/min, 60% duty cycle, 1:5 breath to compression ratio and 25-30 mm Hg peak airway pressure. SCV-CPR was performed at 60 compressions/min, 60% duty cycle and 60 mm Hg peak airway pressure applied during each chest compression. Peak right atrial and aortic pressures in excess of $0 mm Hg were generated during CPR in both groups. At 5 min of conventional and SCV-CPR, MBF was 38 ± 7 and 46 ± 7 mL min-1 100 g-1