Mixed ligands biologically active complexes of cobalt(II), copper(II) and nickel(II) with nicotinoylhydrazine-derived ONO, NNO and SNO donor Schiff-base ligands having the same metal ion but different anions such as sulphate, nitrate, oxalate and acetate have been synthesised and characterised on the basis of their physical, analytical and spectral data. In order to evaluate the role of anions on their bioability, these ligands and their synthesised metal complexes with various anions have been screened against bacterial species such as Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus and the title studies have proved a definative role of anions in increasing the biological activity.
Chohan, Z. H., & Rauf, A. (1996). Pharmacological role of anions (sulphate, nitrate, oxalate and acetate) on the antibacterial activity of cobalt(II), copper(II) and nickel(II) complexes with nicotinoylhydrazine- derived ONO, NNO and SNO ligands. Metal-Based Drugs, 3(5), 211–217. https://doi.org/10.1155/MBD.1996.211