Prevalence of the BRCA1 c.6869delAG (BIC: 185delAG) mutation in women with breast cancer from north-central Poland and a review of the literature on other regions of the country

Abstract

Aim of the study: Germline mutations in BRCA tumor suppressor genes are strongly associated with breast and ovarian cancer. The lifetime risk of these cancers in women with BRCA1 mutation is 84% and 27%, respectively. Studies on the prevalence of BRCA1 c.6869delAG congenital mutation, the most frequent in Ashkenazi Jews, among women with breast cancer from northcentral Poland and review of the literature on other regions of the country. Evaluation of the c.6869delAG association with breast cancer risk, with respect to women's age at diagnosis and family history of cancer. Material and methods: 252 women with breast cancer, without any of the mutations c.5266dupC, c.181T