SOX9 Duplication Linked to Intersex in Deer

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Abstract

A complex network of genes determines sex in mammals. Here, we studied a European roe deer with an intersex phenotype that was consistent with a XY genotype with incomplete male-determination. Whole genome sequencing and quantitative real-time PCR analyses revealed a triple dose of the SOX9 gene, allowing insights into a new genetic defect in a wild animal. © 2013 Kropatsch et al.

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Kropatsch, R., Dekomien, G., Akkad, D. A., Gerding, W. M., Petrasch-Parwez, E., Young, N. D., … Epplen, J. T. (2013). SOX9 Duplication Linked to Intersex in Deer. PLoS ONE, 8(9). https://doi.org/10.1371/journal.pone.0073734

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