Myeloid-derived suppressor sells and the efficacy of CD8+ T-cell immunotherapy

Abstract

Myeloid-derived suppressor cells (MDSCs) promote immune evasion, a key feature of oncogenesis. The restoration of immunosurveillance by immunomodulatory antibodies improves the survival of a subset of cancer patients. Preclinical studies suggest that the ablation of monocytic MDSCs may be a useful adjunct to available immunotherapeutic strategies against cancer. © 2013 Landes Bioscience.